PRF for Hair Loss

Platelet-rich plasma (PRP) treatment has gained popularity in recent years as a non-surgical option for hair loss, but have you heard of platelet-rich fibrin (PRF)? While both PRP and PRF are derived from a patient’s own blood and involve the use of platelets, there are some key differences between the two treatments. In this blog post, we’ll delve into what PRF is and how it differs from PRP. We’ll also discuss the scientific basis for using PRF treatments to stimulate hair growth and explore the potential benefits and risks of this treatment option. By the end of this post, you’ll have a better understanding of PRF hair loss treatments and whether it might be right for you.

PRP vs. PRF Hair Restoration

Platelet-rich fibrin (PRF) is a type of platelet concentrate that is derived from a patient’s own blood. It is created through a process called centrifugation, in which whole blood is spun in a special machine to separate the different components of the blood, including the platelets, white blood cells, and red blood cells.

PRF is similar to platelet-rich plasma (PRP) in that it contains a high concentration of platelets, which are blood cells that play a key role in the body’s healing and repair processes. However, PRF therapy is different from PRP therapy in that it has been “activated” to stimulate the production of fibrin, a protein that helps to form blood clots and supports tissue repair. Some believe that PRF has advantages that relate to tissue healing and regeneration compared to PRP. For this reason PRF is sometimes called an “advanced version” of PRP.


PRF treatments have been used in various medical and dental procedures to stimulate tissue healing and regeneration, and it is increasingly being explored as a treatment option for hair loss. Some studies have suggested that PRF hair restoration procedures may be more effective at stimulating hair growth than PRP, although more research is needed to confirm these findings.

How is PRF Made?

A syringe full of PRP in front of a centrifuge

To create platelet-rich fibrin (PRF), a clinician will first perform a blood draw, typically through a vein in the patient’s arm. The blood is then placed in a special tube, called a PRP Kit that is designed to separate the different components of the blood through a process called centrifugation.


During centrifugation, the patient’s blood is spun in a special machine at high speeds, which causes the heavier components, such as the red blood cells and white blood cells, to settle to the bottom of the tube. The lighter, more liquid portion of the blood, called the plasma, rises to the top of the tube. In the middle layer of the tube, a concentration of platelets and fibrin is created. This is the PRF.

The PRF is then carefully collected and prepared for use in the treatment. PRF is used for a wide variety of medical treatments, ranging from surgical to aesthetic. In aesthetic medicine, PRF is typically injected into face to stimulate collagen growth or into the scalp to stimulate hair growth. The treatment is usually performed by a healthcare professional, such as a dermatologist or plastic surgeon, in a clinical setting.


PRF treatment is a quick and relatively painless process, and it does not require any incisions or stitches. It is also an autologous treatment, meaning that it uses the patient’s own blood, so there is little risk of allergic reactions or other adverse effects. However, as with any medical procedure, there is some risk of side effects or complications, so it is important to discuss these with a healthcare professional before undergoing treatment.

Does PRF Stimulate Hair Growth?

young blonde woman receiving a prp injection into her hairline near her part form gloved hands

Platelet-rich fibrin (PRF) is thought to stimulate hair growth through a process called angiogenesis. Angiogenesis refers to the growth of new blood vessels, which is necessary for the delivery of oxygen and nutrients to the hair follicles. Studies have shown that platelets contain growth factors that help to stimulate angiogenesis and support tissue repair and regeneration.


There is some clinical evidence to suggest that PRF hair restoration procedures may be effective at stimulating hair growth in patients with hair loss conditions such as androgenetic alopecia (male or female pattern baldness) and alopecia areata (an autoimmune disorder that causes hair loss). Much more clinical research has been conducted using PRP to treat hair loss conditions than PRF, however these two types of treatments have more similarities than differences.

How PRF Affects Hair Follicles

When PRF (platelet-rich fibrin) is injected into the scalp, it can stimulate dormant hair follicles and promote new hair growth. This is thought to be due to the high concentration of platelets and growth factors that are present in PRF. These growth factors can stimulate the proliferation of cells in the hair follicle, including stem cells, which are important for the growth and maintenance of hair.


A PRF hair loss treatment can also improve blood flow to the hair follicles, which can help to nourish the hair and restore hair growth. In addition, PRF hair treatments may help to reduce inflammation in the scalp, which can be a contributing factor to hair loss.

Growth Factors in PRF for Hair Regrowth

Growth factors are proteins that play a crucial role in the growth and development of cells and tissues. They are important for many different processes in the body, including cell division, tissue repair, and the formation of new blood vessels.


PRF contains a high concentration of growth factors, which are believed to play a role in its effectiveness as a hair loss treatment. When PRF is injected into the scalp, the growth factors present in the solution can stimulate the proliferation of cells in the hair follicle, including stem cells. This can help to promote the growth of new hair.


Some of the growth factors present in PRF that may be particularly important for hair regrowth include vascular endothelial growth factor (VEGF), transforming growth factor-beta (TGF-beta), and platelet-derived growth factor (PDGF). These growth factors are involved in the formation of new blood vessels and the proliferation of cells, which can both be important for healthy hair growth.

PRF Treatment for Thinning Hair

Man checking his receding hairline in mirror

Most people will experience some amount of hair loss or thinning hair in their lifetime. There are many different causes of thinning hair, including genetics, hormonal imbalances, certain medications, and underlying health conditions. One common cause of thinning hair is androgenetic alopecia, also known as male pattern baldness or female pattern baldness, which is caused by an overproduction of the hormone testosterone.


A PRF hair loss treatment may be effective for thinning hair in some cases. As mentioned previously, PRF has been shown to stimulate the growth of hair follicles and improve overall scalp health in some patients. This can help to promote the growth of thicker, healthier hair.


In addition, a PRF procedure may be helpful for individuals with thinning hair due to underlying health conditions or medications. For example, PRF injections may be able to improve blood flow to the scalp and reduce inflammation, which can both be contributing factors to hair loss.


It is important to note that a PRF hair loss treatment is not a one-size-fits-all solution for thinning hair. The effectiveness of PRF will depend on the individual’s specific cause of hair loss and other factors.

How many Treatments for New Hair Growth?

male patient having a bald spot on the back of his scalp examined by a dermatologist

It is important to consult with a healthcare provider to determine the appropriate number of PRF treatments for your specific needs. Patients experience hair thinning for a variety of reasons ranging from genetic predisposition (androgenic alopecia) to tight hairstyles (traction alopecia).


Typically the first thing a clinician will do is determine whether or not a patient is a good candidate for a PRF hair restoration treatment but identifying the underlying cause of the patient’s hair thinning. By determining why the patient is experiencing hair loss, the clinician can make more informed decisions related to their hair restoration protocol – including the number and frequency of PRF injections that they will perform.


Additionally, the quality of the medical provider’s skill and technique will likely impact the total number of hair restoration injection appointments that a patient will require. The type of medical devices and procedure technique varies widely between providers – and has a significant impact on therapeutic outcomes for patients.

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